I agree with OBD - 2 pristine imbued weapons coupled with a good poison and any proc buffs your castsrs in group can give you will do some pretty insane damage, even if the proc is a low damage amount. Just watch the aggro
Now, there do seem to be some mobs that actually have some type of "damage resistance" where if you don't do at least "X" damage, then they are immune to the attack and all associated effects of the attack (i.e. the procs don't even hit). Its times like that you may wish to keep a 1 handed weapon on hand just so you still can do something during battle.
As for 2-hd swords, according the Prima Guide for EQ2, it says that scouts cannot use 2 handed, of course prima has been known to be wrong often so your best bet is to check it out, and also things can change as they go up in levels.
But really, what swashbuckler uses a 2 handed weapon? They use a rapier and a main-gauche (spelt wrong I know).